Easify Your Lyo Process

Process control with product temperature measurement with Tempris’ unique wireless temperature sensor technology.

Tempris – Product Temperature Measurement in Lyophilization

Product Temperature Measurement is the Most Important Parameter in Lyophilization

Product temperature measurement in Lyophilization is essential for the quality of the product and the optimization of the lyo-cycle. Our innovative wireless technology, as a PAT-Tool, makes your production process cost efficient and time saving with high product quality. Tempris’ uninterrupted continuous process verification (CPV) guarantees reliable quality and optimum productivity.
As Product Temperature Tp is the most critical parameter during the process of Lyophilization, but due development in process optimization (e.g. automatic loading) it is not measured during the actual production on a regular base. Using the wireless Tempris system during this step allows you to

  • Optimize your Lyo process via temperature control
  • Easify to recover products and save money in case of deviation during the lyo process

  • Provide reliable temperature data for regulatory submisson

The same Tempris sensors used in laboratory scale can be used in pilot and production freeze-dryers under cGMP guidelines to obtain directly comparable data. Also Tempris is ideally suited for integration into aseptic automated fill/finish production lines.

See how Tempris Sensor Technology Works

Sensor for Real-time Product Temperature Measurement

Wireless sensor for product temperature measurement inserted in a vial with labeling

We specifically designed Tempris temperature sensors for the monitoring and optimization of freeze-drying processes. They have proven their reliability in many industrial and academic applications. Tempris sensors have a variety of advantages over other sensors measuring temperature in freeze drying

Tempris Technology for Product Temperature Measurement

Tempris – Temperature remote interrogation system

The Tempris Lyophilization Monitoring Software TLM is used to control the interrogation unit (TIRU3), record data, set all parameters, visualize and export data. TLM gets the data of the Tempris Interrogation Unit TIRU3 which in turn gets temperature data from the antennas in the freeze-dryer. The antennas collect all the temperatures which are measured by the quartz based sensor (operating on the principle of temperature dependent resonance).

Overview over all parts of the Tempris product temperature measurement solution

Tempris fits all Primary Packaging

Tempris sensors are offered in different sizes to fit all types of primary packaging such as different-sized vials, DC syringes, etc.

  • Vials
  • Dual chamber cartridges DCC (Magazine)

  • Lyo Trays (metal or plastic)

  • Lyoguard (Gore-tex) and others
  • Double chamber (DC) syringes

Pfizer’s Experience with Tempris

„Tempris, wireless sensor, allows placement of temperature sensors in any location within freeze-dryer. It is also a sensor of choice if product temperature of edge vials is monitored. Tempris sensor is not releasing heat while wired temperature sensors (thermocouples or data loggers) can transfer some heat into the product (very notable for the edge vials), obscuring the actual product temperature. It is especially very important if small fill volume is used when readings of thermocouples and data loggers from the edge vials produce uncertain temperature profiles.”


Tempris Products – Product Temperature Measurement for all Lyo Scales

Lyo-cycle development in the laboratory establishes the base for the freeze drying cycle and subsequent optimization. When the product moves to a larger freeze-dryer, to a different type of freeze-dryer or simply to cGMP environment it was often necessary to change the Tp measurement technology. This causes problems or limitations with respect of the comparability of the obtained data. With Tempris, the same sensors which are used in lab scale development can also be used in pilot and production scale freeze-dryers at equivalent positions, thus providing directly comparable data.

Laboratory Freeze-Dryer

Typical Shelf Size:
1 – 5 SQFT
0.1 – 0.5 SQM

Product temperature measurement during lyophilization with Tempris sensors in Laboratory Scale

Pilot Freeze-Dryer

Typical Shelf Size:
10 – 50 SQFT
1 – 5 SQM

Product temperature measurement during lyophilization with Tempris sensors in Pilot Scale

Production Freeze-Dryer

Typical Shelf Size:
100 – 500 SQFT
10 – 50 SQM

Product temperature measurement during lyophilization with Tempris sensors in Production Scale

Automated Sensor Loading by Robot

Fully automated aseptic sensor loading by robot according to GMP Annex 1 ensures the highest aseptic safety level. Each sensor is checked for the correct vial-size, identified and recorded for accurate process repetition and batch comparison. Pre-prepared vials with sensors are loaded automatically in the predefined critical positions.

A Robot loads Vials with Tempris Sensors automatically in an aseptic environement
Automatical loading of Vials with Tempris Sensors for Product temperature measurement with a Robot

Tempris Services

Tempris offers a wide range of additional services to easify your process and ensure regulatory issues. We accompany you from the decision to measure temperature, through installation and maintenance, to optimising your freeze-drying process with accurate temperature data. Our service and support includes:

At Your Site

  • IQ/OQ Execution
  • User Training / Technical Support
  • Maintenance / Annual Inspection
  • Measuring Device Calibration

At Tempris HQ

  • Calibration with Traceability
  • Remote User Training
  • Remote Technical Support

Want to become part of Tempris?

We are continuously looking for new talents to join our team. Please feel free to e-mail your job application directly to career@tempris.com.

Four collagues chatting on a stairway
Audience listens to speakers on a stage

Conferences – Meet Us Personally

Tempris regularly attends conferences and trade shows all over the world. We would be glad to meet you there and tell you more about our solution for product temperature measurement in lyophilization.