Temperature Measurement Technology

Tempris has developed a unique temperature measurement technology for use in the freeze-drying process. This wireless, battery-free, and real-time technology allows for the measurement of product temperature during the freeze-drying process. Thus temperature measurement technology provides amazing opportunities for process optimization and product quality improvement.

Below you find further information to the Tempris software and hardware.

TLM – Tempris Lyophilization Monitoring Software

The Tempris Lyophilization Monitoring Software TLM is used to control the measuring unit, record data, set all parameters, visualize and export data. TLM complies with GAMP 5 / 21CFR Part 11.

  • 40 sensors simultaneously
  • Sensor function test for robot-assisted loading

  • Visualization of the measured data

  • Sensor positioning plan (loading plan)

  • 3D representation of the sensor positions
  • Input primary packaging – size, capacity, type, etc.
  • Modern Windows design
  • Selection of different languages
Screenshot of the Tempris Lyophilization Monitoring Software (TLM)
Screenshot of the Tempris Lyophilization Monitoring Software (TLM) - Close-up

New Application – Visualization of Critical Positions

Introducing the new Tempris software application! With Tempris, you can easily visualize your measurement data in real-time and 3D in the digital twin of your freeze-dryer. This software allows you to identify the critical positions in your freeze-dryer. By identifying these positions early in the system qualification process (PQ runs), you can more efficiently determine measurement data. Tempris makes it easier than ever to visualize and analyze your measurement data. Which trains the users for better process understanding.

You can easily upgrade your current Tempris software with this application.

Key Features:

3D Data Visualization:
We have introduced a graphical 3D analysis tool for visualizing measurement data. This feature enables users to identify Cold and Hot Spots, providing a comprehensive understanding of temperature distribution.

3D Visualization

Automated Logging Configuration:
Users can now configure automatic logging initiation at the start of measurements, streamlining the process and ensuring seamless data recording.

Automatic Loading Start

Time-Stamped User Comments:
During logging sessions, users have the ability to add time-stamped comments, providing valuable context. These comments will be reflected in both graphical representations and report outputs.

Time Marks

Dynamic Sensor Set Switching:
Introducing a new function that allows operators to switch between active sensor sets without accessing sensor configuration data directly. This feature enhances operational flexibility and efficiency.

Select Sensors

Customized User Roles:
Administrators can define personalized user roles in the user management system, tailoring access to specific functions within the Temperature and Logging Management (TLM) system. This ensures a secure and customized user experience.

Customizable User Roles

Improved Signal Processing:
Our updated signal processing algorithms contribute to a more stable system by minimizing temperature outliers, ensuring the accuracy and reliability of your measurements.

Enhanced Backup Log Data:
In addition to temperature data, backup log files now include diagnostic information such as the used antenna and signal strength. This comprehensive data set enhances post-analysis capabilities.

Tempris Hardware

Tempris Interrogation Unit TIRU3

The Tempris provides wireless and battery-free, long-term- and real-time product temperature measurement. The key component of our new measurement system is the control unit, which principally allows for an unlimited number of Tempris sensors.

The main features of our new product generation are:

  • Substantially higher data throughput with improved signal analysis and optional extended data analysis in the lyophilization process
  • Spectral analysis for continuous monitoring of interfering frequencies – such as WiFi and Bluetooth – and automatic switching to alternative frequencies
  • Integrated multiplexer for controlling innovative antenna systems
  • Simplified cabling through Power over Ethernet (PoE)
  • Suitable for complete automation in the SCADA / PLC with sensor identification for loading and unloading
  • Digital identification of sensors via radio signal in combination with the proven quartz sensor technology (pat. pend.) for up to 40 sensors with digital calibration
  • Support of additional frequency bands
  • Designed for ATEX application
  • Features to assist the operator
Image of the Tempris Temperature Interrogation Unit TIRU

Tempris Sensors

The TL sensor model, short for “Temperature measurement lyophilization,” is designed for measuring temperatures in R-vials, H-vials, and injection vials in conjunction with the original stopper. These sensors can also be applied to additional formats such as bulk vials, sealable membrane bags, or even double-chamber cartridges using suitable accessories. Up to 40 sensors can be utilized simultaneously in each run. The TL sensor model comes in five different formats based on packaging materials and filling quantities, with the primary distinguishing factor being the sensor length.

  • Containers: Vials, DCC, Lyoguard, trays, bulk
  • Fill volume (min): e.g. 2 R vial 0.3 ml
  • System Accuracy: ± 0.3 K to ± 0.7 K (standard)
  • Autoclavable: +122°C or +134°C

Tempris Antenna MFA – Our Solution for Production Freeze-Dryer

Welcome to the cutting-edge world of MFA Antenna—a revolutionary solution designed to enhance sensor signal acquisition and streamline processes. MFA, short for “Multi-Functional Antenna,” represents the pinnacle of innovation in antenna technology.
The MFA Antenna System is a robust solution for continuous freeze-drying operations, addressing hot and cold spots to ensure compliance with design space requirements. Optional features enhance sterility and prevent condensation.
In terms of performance, the system allows doubling the number of antennas per interrogation unit, improving signal illumination and sensor positioning to identify hot and cold spots accurately, and optimizing the lyophilization process.

  • Optimized Performance: Unlock superior sensor performance with the MFA Antenna, designed for use in the production freeze-dryer chamber. This advanced capability enables enhanced data acquisition, accommodating up to multiple antennas within the chamber for unparalleled performance.

  • Robust Installation: The MFA Antenna is not just a technological marvel but also a robust solution. Encased in a durable stainless-steel tube, it protects RF connections, ensuring longevity and reliability.

  • Cost-Effective Maintenance: Enjoy peace of mind with minimal maintenance costs. The RF connections are safeguarded within the antenna body, reducing the risk of wear and tear and contributing to long-term cost savings.

  • Easy to Clean: The MFA Antenna boasts a hygienic design with Clean-In-Place (CIP) and Sterilize-In-Place (SIP) compatibility.

MFA Antenna in a freeze-dryer
MFA Antenna - easy to clean
Tempris Antenna ANT-PH1 for production freeze-dryer

Tempris Antenna ANT-PH1

The Tempris ANT-PH1 antenna is a passive module designed for cGMP-compliant freeze-drying processes in API pharmaceutical production. It is specifically recommended for flexible retrofitting in various freeze-drying chambers. All antenna components adhere to CIP/SIP standards, ensuring suitability for continuous operation.
Installation occurs within the chamber using a separate holding rod, fixed, for instance, to the CIP/SIP lance with different clamps. The Tempris team customizes the number and position of antennas based on individual chamber geometry and available flange positions.
Regulatory compliance is ensured, meeting FDA 21 CFR, GAMP 5, and 2001/95/EC (RoHS) standards. The ANT-PH1, with its related accessories, provides an adaptable antenna solution that fits a broad range of freeze dryers. The pre-assembled set includes a single antenna for CIP and SIP applications, along with an angle adapter and clamping rings suitable for a 15 mm diameter rod.

  • Number of ANT-PH1 type antennas: 2 – 8
  • ISM Frequency band: 2.4 GHz
  • Storage Temperature: 0°C … +60°C
  • Operating Temperature: -70°C … +140°C
  • Humidity (max.): < 100 % RH
  • Protection Class: IP68

Tempris Antenna ANT-P3H for Laboratory Freeze-Dryer

The Tempris ANT-P3H antenna is specifically designed for use in laboratory freeze dryers within the pharmaceutical production and development of Active Pharmaceutical Ingredients (API). It is intended for adhesive attachment to an acrylic glass door. To optimize reception quality, users can position sensors within the chamber, adjust plates for desired placement, and easily monitor sensor reception on a PC display. Horizontal and vertical displacement helps find the optimal position, and the antenna holder is then fixed accordingly. Additionally, signal strength can be enhanced by stretching aluminum foil over the acrylic door, commonly employed to reduce radiation strength. The antenna complies with regulatory requirements outlined in 2001/95/EC (RoHS).

  • Storage Temperature:0 °C … +50 °C
  • Operating Temperatur:-20 °C … +60 °C
  • Protection Class:IP43
  • Maximum applicable ANT-P3H per freeze dryer: 2 (depending on amount of sight glasses)
  • Cable Length: 1.20 m
  • Frequency: 2400-2500 MHz
  • Gain: 8 dBi
  • Horizontal Beam Width: 75 degrees
  • Vertical Beam Width: 65 degrees
  • Impedance: 50 Ohm
Tempris Antenna ANT-P3H for laboratory freeze-dryer

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A young man is reading the Tempris Newsletter on his notebook and smiling. Next to him is a microscope and test tubes.