Temperature Measurement Technology
Tempris has developed a unique temperature measurement technology for use in the freeze-drying process. This wireless, battery-free, and real-time technology allows for the measurement of product temperature during the freeze-drying process. Thus temperature measurement technology provides amazing opportunities for process optimization and product quality improvement.
Below you find further information to the Tempris software and hardware.
Tempris Hardware
Tempris Interrogation Unit TIRU3
The Tempris provides wireless and battery-free, long-term- and real-time product temperature measurement. The key component of our new measurement system is the control unit, which principally allows for an unlimited number of Tempris sensors.
The main features of our new product generation are:

Tempris Sensors
The TL sensor model, short for “Temperature measurement lyophilization,” is designed for measuring temperatures in R-vials, H-vials, and injection vials in conjunction with the original stopper. These sensors can also be applied to additional formats such as bulk vials, sealable membrane bags, or even double-chamber cartridges using suitable accessories. Up to 40 sensors can be utilized simultaneously in each run. The TL sensor model comes in five different formats based on packaging materials and filling quantities, with the primary distinguishing factor being the sensor length.
Tempris Antenna MFA
The MFA Antenna System is a robust solution for continuous freeze-drying operations, addressing hot and cold spots to ensure compliance with design space requirements. It monitors temperature, humidity, and pressure, facilitated by TLM software. Optional features enhance sterility and prevent condensation.
In terms of performance, the system allows doubling the number of antennas per interrogation unit, improving signal illumination and sensor positioning to identify hot and cold spots accurately, and optimizing the lyophilization process.
The system’s configuration is considered during freeze dryer design, integrating it into cleaning simulations for successful cleaning validation. Materials and surfaces meet CIP/SIP standards and FDA requirements.
Lastly, the MFA Antenna System’s modular design facilitates easy commissioning, maintenance, and service.


Tempris Antenna ANT-PH1
The Tempris ANT-PH1 antenna is a passive module designed for cGMP-compliant freeze-drying processes in API pharmaceutical production. It is specifically recommended for flexible retrofitting in various freeze-drying chambers. All antenna components adhere to CIP/SIP standards, ensuring suitability for continuous operation.
Installation occurs within the chamber using a separate holding rod, fixed, for instance, to the CIP/SIP lance with different clamps. The Tempris team customizes the number and position of antennas based on individual chamber geometry and available flange positions.
Regulatory compliance is ensured, meeting FDA 21 CFR, GAMP 5, and 2001/95/EC (RoHS) standards. The ANT-PH1, with its related accessories, provides an adaptable antenna solution that fits a broad range of freeze dryers. The pre-assembled set includes a single antenna for CIP and SIP applications, along with an angle adapter and clamping rings suitable for a 15 mm diameter rod.
Tempris Antenna ANT-P3H for Laboratory Freeze-Dryer
The Tempris ANT-P3H antenna is specifically designed for use in laboratory freeze dryers within the pharmaceutical production and development of Active Pharmaceutical Ingredients (API). It is intended for adhesive attachment to an acrylic glass door. To optimize reception quality, users can position sensors within the chamber, adjust plates for desired placement, and easily monitor sensor reception on a PC display. Horizontal and vertical displacement helps find the optimal position, and the antenna holder is then fixed accordingly. Additionally, signal strength can be enhanced by stretching aluminum foil over the acrylic door, commonly employed to reduce radiation strength. The antenna complies with regulatory requirements outlined in 2001/95/EC (RoHS).
